There is some excellent advice in this thread, and some fairly inaccurate info all the same. For clarity, I have hours of experience logging on Ecoboosts with various fuels and tunes, and I have a BS in Chemistry...so I might know what I am talking about.
1) Let's clarify BTU and Octane first. They are not directly related. In the past there was a correlation(will explain in a sec). 87/89/91/93 from the same station should have the same BTU's in most cases. Assuming they are all the same E(Ethanol) content. That being said, in the past(30+) years ago, it was actually quite the opposite of what one of the posts said above, 87 had higher BTU's than most 93 out there. The reason being the refinement process. The process actually had the negative result of decreasing the energy content, between the byproducts and additives, but the Octane was higher. Octane is merely the fuels ability to resist knock. Ethanol treated gas, typically E10, will have less BTU's than E0 and will get slightly less MPG if compared back to back under the same conditions.
2) Power Ratings, recommended Octane, and factory tuning. Power ratings and MPG's are based off a Federal standard using a fuel that is basically equivalent to 91(E10) Octane gas. It actually isn't really Gasoline, but it is a standard, so that all manufacturers that use the standard are on the same playing field. Anything less than 91(E10) and you are getting less than rated power most likely. EcoBoost motors to state it simply do not "Tune Up" to fuel they detune. Basically they ask for a certain power level(rated), and the Turbo, Fuel system and other things meet that demand. If knock is sensed, timing is pulled, fuel is decreased, and boost is decreased.
3) Ethanol vs Non-Ethanol Fuel. E10 is ALWAYS better for an Ecoboost vs E0. Ethanol has additional advantages like cooling and cleaning above it's octane advantages. Yes, if driving easy E0 91/93 will get you your best MPG, and will be slightly better than E10 91/93. E10 91/93 will yield the most power stock, and give the best experience all around.
Here is a good article to read...actual Data:
https://www.caranddriver.com/features/a28565486/honda-cr-v-vs-bmw-m5-ford-f-150-dodge-charger/